Stem Cell Prolotherapy

Journal of Prolotherapy Stem Cell Therapy

1. Vangsness CT Jr, Farr J 2nd, Boyd J, Dellaero DT, Mills CR, LeRoux-Williams M. Adult human mesenchymal stem cells delivered via intra-articular injection to the knee following partial medial meniscectomy: a randomized, double-blind, controlled study. J Bone Joint Surg Am. 2014 Jan 15;96(2):90-8. doi: 10.2106/JBJS.M.00058. PubMed [citation] PMID: 24430407

2. Cui L, Wu Y, Cen L, Zhou H, Yin S, Liu G, Liu W, Cao Y. Repair of articular cartilage defect in non-weight bearing areas using adipose derived stem cells loaded polyglycolic acid mesh. Biomaterials. 2009 May;30(14):2683-93. doi: 10.1016/j.biomaterials.2009.01.045. Epub 2009 Feb 12. PubMed [citation] PMID: 19217157

3. Dragoo JL, Carlson G, McCormick F, Khan-Farooqi H, Zhu M, Zuk PA, Benhaim P. Healing full-thickness cartilage defects using adipose-derived stem cells. Tissue Eng. 2007 Jul;13(7):1615-21. PubMed [citation] PMID: 17518742

4. Wakitani S, Goto T, Pineda SJ, Young RG, Mansour JM, Caplan AI, Goldberg VM. Mesenchymal cell-based repair of large, full-thickness defects of articular cartilage. J Bone Joint Surg Am. 1994 Apr;76(4):579-92. PubMed [citation] PMID: 8150826

5. Black LL, Gaynor J, Adams C, Dhupa S, Sams AE, Taylor R, Harman S, Gingerich DA, Harman R. Effect of intraarticular injection of autologous adipose-derived mesenchymal stem and regenerative cells on clinical signs of chronic osteoarthritis of the elbow joint in dogs. Vet Ther. 2008 Fall;9(3):192-200. PubMed [citation] PMID: 19003780

6. Centeno CJ, Busse D, Kisiday J, Keohan C, Freeman M, Karli D. Increased knee cartilage volume in degenerative joint disease using percutaneously implanted, autologous mesenchymal stem cells. Pain Physician. 2008 May-Jun;11(3):343-53. PubMed [citation] PMID: 18523506

7. Pak J. Regeneration of human bones in hip osteonecrosis and human cartilage in knee osteoarthritis with autologous adipose-tissue-derived stem cells: a case series. J Med Case Rep. 2011 Jul 7;5:296. doi: 10.1186/1752-1947-5-296. PubMed [citation] PMID: 21736710, PMCID: PMC3154169

8. Jo CH, Lee YG, Shin WH, Kim H, Chai JW, Jeong EC, Kim JE, Shim H, Shin JS, Shin IS, Ra JC, Oh S, Yoon KS. Intra-articular injection of mesenchymal stem cells for the treatment of osteoarthritis of the knee: a proof-of-concept clinical trial. Stem Cells. 2014 May;32(5):1254-66. doi: 10.1002/stem.1634. Erratum in: Stem Cells. 2017 Jun;35(6):1651-1652. PubMed [citation] PMID: 24449146

9. Adipose Mesenchymal Stromal Cell-Based Therapy for Severe Osteoarthritis of the Knee: A Phase I Dose-Escalation Trial. Pers YM, Rackwitz L, Ferreira R, Pullig O, Delfour C, Barry F, Sensebe L, Casteilla L, Fleury S, Bourin P, Noël D, Canovas F, Cyteval C, Lisignoli G, Schrauth J, Haddad D, Domergue S, Noeth U, Jorgensen C, on behalf of the ADIPOA Consortium.

Stem Cells Translational Medicine. 2016 May 23; 5(7): 847-856 PMC [article] PMCID: PMC4922848, PMID: 27217345, DOI: 10.5966/sctm.2015-0245

Platelet Rich Plasma

Treatment of Tendons and Muscle Using Platelet Rich Plasma

Platelet Rich Plasma 

Journal of Prolotherapy Maui Training 2010

Components of Platelet Rich Plasma 

Modulation of Wound Response with Platelets

Non-Surgical Repair of Patellar Tendonitis

Hormone Therapy

Testosterone therapy in women: Myths and misconceptions

Beneficial effects of testosterone therapy in women measured by the validated Menopause Rating Scale

Peer Reviewed Journals

Biofeedback Assessment

Intra-articular injection of an autologous preparation rich in growth factors for the treatment of knee OA: a retrospective cohort study
To obtain preliminary information about the effectiveness of intra-articular injections of autologous preparation rich in growth factors (PRGF) for knee OA treatment to be explored further in future studies. Methods. We have characterized PRGF

Platelet-rich plasma: growth factors and pro-and anti-inflammatory properties
Platelet-rich plasma (PRP) promotes regeneration of bone, presumably through the action of concentrated growth factors. However, it is not clear how PRP affects the inflammatory response. The purpose of this study was to analyze the growth factors in …

Infiltration of plasma rich in growth factors for osteoarthritis of the knee short-term effects on function and quality of life
Abstract Purpose Osteoarthritis (OA) is a highly prevalent, chronic, degenerative condition that generates a high expense. Alternative and co-adjuvant therapies to improve the quality of life and physical function of affected patients are currently being sought. Methods A total …

Treatment With Platelet-Rich Plasma Is More Effective Than Placebo for Knee Osteoarthritis A Prospective, Double-Blind, Randomized Trial
Methods: A total of 78 patients (156 knees) with bilateral OA were divided randomly into 3 groups. Group A (52 knees) received a single injection of PRP, group B (50 knees) received 2 injections of PRP 3 weeks apart, and group C (46 knees) received a single injection of …

Use of autologous platelet-rich plasma to treat muscle strain injuries
Muscle strains are one of the most common injuries treated by physicians. Standard conservative therapy for acute muscle strains usually involves short-term rest, ice, and non-steroidal anti-inflammatory medications, but there is no clear consensus on how to accelerate recovery.

Treatment of Achilles tendinopathy with platelet-rich plasma
Abstract Non-insertional Achilles tendinopathy commonly impedes the functioning of active persons. Treatment methods vary, as do their results. The aim of the study was to evaluate the effectiveness of non-insertional Achilles tendinopathy treatment with autologous …

Platelet-rich plasma treatment in symptomatic patients with knee osteoarthritis preliminary results in a group of active patients
With increasing frequency, platelet-rich plasma (PRP) preparations have been used to treat cartilage lesions to regenerate tissue homeostasis and retard the progression of knee osteoarthritis (OA). Purpose: To determine the effectiveness of intra-articular PRP …

Platelet quantification and growth factor analysis from platelet-rich plasma: implications for wound healing
Abstract Growth factors released from activated platelets initiate and modulate wound healing in both soft and hard tissues. A recent strategy to promote the wound-healing cascade is to prepare an autologous platelet concentrate suspended in plasma, also …

Platelet-rich plasma intra-articular injection versus hyaluronic acid viscosupplementation as treatments for cartilage pathology: from early degeneration to …
The aim of this study is to compare the efficacy of platelet-rich plasma (PRP) and viscosupplementation (hyaluronic acid [HA]) intra-articular injections for the treatment of knee cartilage degenerative lesions and osteoarthritis (OA).

Use of platelet-rich plasma for the treatment of refractory jumper’s knee
Abstract The aim of this study was to evaluate the efficacy of multiple platelet-rich plasma (PRP) injections on the healing of chronic refractory patellar tendinopathy after previous classical treatments have failed. We treated 15 patients affected by chronic jumper’s knee, …

Ongoing Positive Effect of Platelet-Rich Plasma Versus Corticosteroid Injection in Lateral Epicondylitis A Double-Blind Randomized Controlled Trial With 2-year …
Platelet-rich plasma (PRP) has been shown to be a general stimulation for repair and 1-year results showed promising success percentages. Purpose: This trial was undertaken to determine the effectiveness of PRP compared with corticosteroid injections …

Positive effect of an autologous platelet concentrate in lateral epicondylitis in a double-blind randomized controlled trial platelet-rich plasma versus corticosteroid …
Platelet-rich plasma (PRP) has shown to be a general stimulation for repair. … Purpose To determine the effectiveness of PRP compared with corticosteroid injections in patients with chronic lateral epicondylitis. … Study Design Randomized controlled trial; Level of evidence, 1. … Patients The trial was conducted in 2 teaching hospitals in the Netherlands. One hundred patients …

Treatment of chronic elbow tendinosis with buffered platelet-rich plasma
Elbow epicondylar tendinosis is a common problem that usually resolves with nonoperative treatments. When these measures fail, however, patients are interested in an alternative to surgical intervention. … Hypothesis: Treatment of chronic severe elbow tendinosis with buffered platelet-rich plasma will reduce pain and …

Injection of platelet-rich plasma in patients with primary and secondary knee osteoarthritis: a pilot study
Injection of platelet-rich plasma in patients with primary and secondary knee osteoarthritis: A pilot study. Objective: To evaluate the clinical effects of intraarticular platelet-rich plasma (PRP) injections in a small group of patients with primary and secondary osteoarthritis. Most of the current treatments for osteoarthritis are palliative and attack the symptoms rather than influencing the biochemical environment of the joint. Autologous platelet-rich plasma has emerged as …