Regenerative Injections Using Umbilical Cord Matrix MSC (Mesenchymal Stem Cells)

Regenerative potential of Wharton’s jelly-derived mesenchymal stem cells: A new horizon of stem cell therapy.

Abbaszadeh H, Ghorbani F, Derakhshani M, Movassaghpour AA, Yousefi M, Talebi M, Shamsasenjan K.
J Cell Physiol. 2020 Dec;235(12):9230-9240. doi: 10.1002/jcp.29810. Epub 2020 Jun 18.

Umbilical cord-derived Wharton’s jelly for regenerative medicine applications

Ashim Gupta,1,2,3,4 Saadiq F. El-Amin, III,1,5 Howard J. Levy,1,6 Rebecca Sze-Tu,7 Sobrasua E. Ibim,8 and Nicola Maffulli

Enhancement of acellular cartilage matrix scaffold by Wharton’s jelly mesenchymal stem cell-derived exosomes to promote osteochondral regeneration

Shuangpeng Jiang 1 2Guangzhao Tian 2 3Zhen Yang 2 3Xiang Gao 1Fuxin Wang 2Juntan Li 1Zhuang Tian 2Bo Huang 2Fu Wei 2Xinyu Sang 2Liuqi Shao 2Jian Zhou 2Zhenyong Wang 2Shuyun Liu 2Xiang Sui 2Quanyi Guo 2Weimin Guo 2Xu Li 1

Implication of Mesenchymal Stem Cells and Their Derivates for Osteochondral Regeneration

Veronika Smolinska 1 2Michaela Debreova 2Martina Culenova 1 2Maria Csobonyeiova 3Andrey Svec 4Lubos Danisovic 1 2

Human umbilical cord Wharton’s jelly mesenchymal stem cells combined with an acellular cartilage extracellular matrix scaffold improve cartilage repair compared with microfracture in a caprine model

Y Zhang 1S Liu 2W Guo 2M Wang 2C Hao 3S Gao 4X Zhang 5X Li 6M Chen 2X Jing 7Z Wang 2J Peng 2S Lu 2Q Guo 8

State of the Art: The Immunomodulatory Role of MSCs for Osteoarthritis

Dae Gyu Kwon 1Myung Ku Kim 1Yoon Sang Jeon 1Yoon Cheol Nam 1Jin Seong Park 1Dong Jin Ryu 1

Publications Regarding The Use Of Exosomes For Orthopedics Regenerative Medicine

Mesenchymal stem cell derived-exosomes: a modern approach in translational medicine

Sepideh NikfarjamJafar RezaieNaime Majidi Zolbanin & Reza Jafari Journal of Translational Medicine volume 18, Article number: 449 (2020) 

Mesenchymal Stem Cell-Derived Exosomes and Other Extracellular Vesicles as New Remedies in the Therapy of Inflammatory Diseases

Carl Randall Harrell 1Nemanja Jovicic 2Valentin Djonov 3Nebojsa Arsenijevic 2Vladislav Volarevic 2

Stem Cell-Derived Extracellular Vesicles and Kidney Regeneration

Cristina Grange 1Renata Skovronova 2Federica Marabese 3 4Benedetta Bussolati 5

Cartilage Repair by Mesenchymal Stem Cell-Derived Exosomes: Preclinical and Clinical Trial Update and Perspectives

Leila Taghiyar 1Shahrbano Jahangir # 1Mojtaba Khozaei Ravari # 1Mohammad Amin Shamekhi 2Mohamadreza Baghaban Eslaminejad 3

Roles of Exosomes from Mesenchymal Stem Cells in Treating Osteoarthritis

Jian Wang 1Xuanxuan Guo 1Zhanrong Kang 2Lingbin Qi 3Ying Yang 4Juan Wang 5Jun Xu 1Shane Gao 1

The role and therapeutic potential of MSC-derived exosomes in osteoarthritis

Chuncha Bao 1Chengqi He 2

The Therapeutic Potential of Exosomes in Soft Tissue Repair and Regeneration

Rou Wan 1Arif Hussain 1Atta Behfar 2 3 4Steven L Moran 1Chunfeng Zhao 5

Mesenchymal stem cell-derived exosomes: therapeutic implications for rotator cuff injury

Jinbing He 1Shuai Ping 2Fangyang Yu 2Xi Yuan 1Jiang Wang 1Jun Qi 1

Therapeutic potential of exosomes in rotator cuff tendon healing

Denton E Connor 1Jordan A Paulus 1Parinaz Jila Dabestani 1Finosh K Thankam 1Matthew F Dilisio 1 2R Michael Gross 1 2Devendra K Agrawal 3

Platelet Rich Plasma

Treatment of Tendons and Muscle Using Platelet Rich Plasma

Components of Platelet Rich Plasma 

Non-Surgical Repair of Patellar Tendonitis

Peer Reviewed Journals

Biofeedback Assessment

Intra-articular injection of an autologous preparation rich in growth factors for the treatment of knee OA: a retrospective cohort study
To obtain preliminary information about the effectiveness of intra-articular injections of autologous preparation rich in growth factors (PRGF) for knee OA treatment to be explored further in future studies. Methods. We have characterized PRGF

Platelet-rich plasma: growth factors and pro-and anti-inflammatory properties
Platelet-rich plasma (PRP) promotes regeneration of bone, presumably through the action of concentrated growth factors. However, it is not clear how PRP affects the inflammatory response. The purpose of this study was to analyze the growth factors in …

Infiltration of plasma rich in growth factors for osteoarthritis of the knee short-term effects on function and quality of life
Abstract Purpose Osteoarthritis (OA) is a highly prevalent, chronic, degenerative condition that generates a high expense. Alternative and co-adjuvant therapies to improve the quality of life and physical function of affected patients are currently being sought. Methods A total …

Treatment With Platelet-Rich Plasma Is More Effective Than Placebo for Knee Osteoarthritis A Prospective, Double-Blind, Randomized Trial
Methods: A total of 78 patients (156 knees) with bilateral OA were divided randomly into 3 groups. Group A (52 knees) received a single injection of PRP, group B (50 knees) received 2 injections of PRP 3 weeks apart, and group C (46 knees) received a single injection of …

Use of autologous platelet-rich plasma to treat muscle strain injuries
Muscle strains are one of the most common injuries treated by physicians. Standard conservative therapy for acute muscle strains usually involves short-term rest, ice, and non-steroidal anti-inflammatory medications, but there is no clear consensus on how to accelerate recovery.

Treatment of Achilles tendinopathy with platelet-rich plasma
Abstract Non-insertional Achilles tendinopathy commonly impedes the functioning of active persons. Treatment methods vary, as do their results. The aim of the study was to evaluate the effectiveness of non-insertional Achilles tendinopathy treatment with autologous …

Platelet-rich plasma treatment in symptomatic patients with knee osteoarthritis preliminary results in a group of active patients
With increasing frequency, platelet-rich plasma (PRP) preparations have been used to treat cartilage lesions to regenerate tissue homeostasis and retard the progression of knee osteoarthritis (OA). Purpose: To determine the effectiveness of intra-articular PRP …

Platelet quantification and growth factor analysis from platelet-rich plasma: implications for wound healing
Abstract Growth factors released from activated platelets initiate and modulate wound healing in both soft and hard tissues. A recent strategy to promote the wound-healing cascade is to prepare an autologous platelet concentrate suspended in plasma, also …

Platelet-rich plasma intra-articular injection versus hyaluronic acid viscosupplementation as treatments for cartilage pathology: from early degeneration to …
The aim of this study is to compare the efficacy of platelet-rich plasma (PRP) and viscosupplementation (hyaluronic acid [HA]) intra-articular injections for the treatment of knee cartilage degenerative lesions and osteoarthritis (OA).

Use of platelet-rich plasma for the treatment of refractory jumper’s knee
Abstract The aim of this study was to evaluate the efficacy of multiple platelet-rich plasma (PRP) injections on the healing of chronic refractory patellar tendinopathy after previous classical treatments have failed. We treated 15 patients affected by chronic jumper’s knee, …

Ongoing Positive Effect of Platelet-Rich Plasma Versus Corticosteroid Injection in Lateral Epicondylitis A Double-Blind Randomized Controlled Trial With 2-year …
Platelet-rich plasma (PRP) has been shown to be a general stimulation for repair and 1-year results showed promising success percentages. Purpose: This trial was undertaken to determine the effectiveness of PRP compared with corticosteroid injections …

Positive effect of an autologous platelet concentrate in lateral epicondylitis in a double-blind randomized controlled trial platelet-rich plasma versus corticosteroid …
Platelet-rich plasma (PRP) has shown to be a general stimulation for repair. … Purpose To determine the effectiveness of PRP compared with corticosteroid injections in patients with chronic lateral epicondylitis. … Study Design Randomized controlled trial; Level of evidence, 1. … Patients The trial was conducted in 2 teaching hospitals in the Netherlands. One hundred patients …

Treatment of chronic elbow tendinosis with buffered platelet-rich plasma
Elbow epicondylar tendinosis is a common problem that usually resolves with nonoperative treatments. When these measures fail, however, patients are interested in an alternative to surgical intervention. … Hypothesis: Treatment of chronic severe elbow tendinosis with buffered platelet-rich plasma will reduce pain and …

Injection of platelet-rich plasma in patients with primary and secondary knee osteoarthritis: a pilot study
Injection of platelet-rich plasma in patients with primary and secondary knee osteoarthritis: A pilot study. Objective: To evaluate the clinical effects of intraarticular platelet-rich plasma (PRP) injections in a small group of patients with primary and secondary osteoarthritis. Most of the current treatments for osteoarthritis are palliative and attack the symptoms rather than influencing the biochemical environment of the joint. Autologous platelet-rich plasma has emerged as …